Acetyl-L-Carnitine Review

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Acetyl-l-Carnitine (ALCAR) is a genuine multi-purpose nootropic supplement that has positive effects on both body and brain. ALCAR is powerful neuroprotectant and antioxidant famous for its potent nootropic properties. It also reduces the effects of aging and boosts energy. It is the most effective when combined with other smart drugs. Many people consider ALCAR a crucial element in nootropic stacks and it is becoming more and more popular to use in nootropic stacks alongside choline sources.

ALCAR is a form of the micronutrient L-carnitine. This is a derivative of the amino acid lysine (a building block for proteins). L-carnitine is naturally produced in the body, but it can also be synthesized from animal proteins in the diet. It was named carnitine (a derivation of the Latin word for meat) because it was first isolated from meat in 1905. Although experts claim that actual carnitine insufficiency is pretty rare in healthy individuals with no metabolic disorders, supplementation has shown to be of considerable benefits in many ways, from increasing brain function to improving heart health.

Product Description:

ALCAR is absorbed through the intestines and you can use sodium to improve this absorption rate.

While athletes and bodybuilders take this supplement to help them build muscle, the acetylated version is more usually used for cognitive improvement.

ALCAR is one of the several types of L-carnitine supplements. They are all have been comprehensively studied and they have been proven to provide important mental and physical benefits. ALCAR is believed to be the most bioavailable type of L-carnitine. ALCAR acts within the brain and readily crosses the blood-brain barrier, unlike other types of L-carnitine that help convert fat to energy in the body. ALCAR’s main actions are associated with brain function.

General thoughts:


Studies have shown that ALCAR has positive effects on both the body and brain in an amazing variety of ways, including decreasing pain, minimising harm from alcohol usage, increasing cognitive abilities and boosting energy.

Possible Treatment for Age-Related  Neurological Disorders

A treatment for age-related disorders, including Alzheimer’s Disease is probably one of ALCAR’s most amazing benefits. It has been proven to efficiently decrease age-related memory loss and slow decline in Alzheimer’s patients. It has also been shown that ALCAR helps improve ambulatory capability in the elderly and acts as antidepressant and mood booster in the aged.

An Efficient Neuroprotectant

There is also a lot of evidence to suggest that ALCAR acts as a neuroprotectant. As a potent antioxidant, ALCAR prevents and even repairs damage caused by free radicals which damage and scavenge brain cells. It also helps the brain remove other poisons and toxins. ALCAR strengthens signal receptors and nerves and thus improves the neural network and it also keeps your brain cells healthier in the long run. ALCAR has even been proven to protect the brain against the negative effects of using alcohol.

Cognitive Booster

One of the most important benefits of ALCAR is the potential to improve different brain functions associated to mental processing and intellect. Studies have proven that ALCAR successfully improves learning ability, increases cognitive function and decreases mental fatigue.

Because of an increase in the levels of the neurotransmitter Acetylcholine, people who take ALCAR will experience an increase in overall mental energy, their memory and learning capacity. This help people who take this supplement to maintain an improved focus and a clarity of thought.

ALCAR supplementation is proven to boost the action of other nootropic supplements, such as Racetams.

Physical Health Benefits

Nootropic capabilities are only a part of what Acetyl-L-Carnitine can offer. Many studies have proven the efficiency of ALCAR in the prevention and treatment of many diseases and disorders. This includes physical disorders usually related with aging, including diabetes, metabolic syndrome and high blood pressure. ALCAR has also been proven to be efficient in treating cardiovascular disease, improving kidney function and treating nerve pain.

It has also been proven to increase sperm motility and treat male infertility, which is very important for any men suffering with fertility problems. ALCAR is sometimes used to ameliorate the symptoms of erectile dysfunction and andropause. It is also used to fight Peyronie’s disease (an inflammatory condition which affects the penis). It can possibly alleviate some of the symptoms connected with AIDS and HIV.

ALCAR is currently been studied as a potential treatment for chronic fatigue syndrome and as an additional treatment for fatigue in people who have cancer.

How It Works

Acetyl-L-Carnitine is synthesized primarily in the kidneys and liver and then transported to other tissues. It has great bioavailability and is absorbed through the gastrointestinal tract and is capable of crossing over the blood-brain barrier. Once absorbed, ALCAR enters into the central nervous system and starts exerting its effects.

As ALCAR breaks down it is believed to actually become a precursor for Acetylcholine, which is a potent neurotransmitter that has a crucial role in formation of memory and many other cognitive processes. Acetylcholine is made up of acetate (that you can get from Acetyl-L-Carnitine) and choline.

Potent Neuroprotection

Strengthening the protective myelin sheath which surrounds the brain nerves is one of the most important ways that Acetyl-L-Carnitine improves cognitive function and safeguards the brain. Damage or weakening to the myelin sheath has a serious negative effect on coordination, balance hearing, vision and general brain function.

Acetyl-L-Carnitine has also been proven to help keep neurons functional and healthy and protect membrane signals receptors in the brain. This protective ability not only enhances ability to form and maintain new memories, it is another way in which Acetyl-L-Carnitine potentiates and complements other nootropic supplements.

Increased Brain Metabolism

Acetyl-L-Carnitine also targets brain metabolism, acting as a potent neuroprotectant and increasing cellular energy. Its significant antioxidant characteristics decrease the amount of damaged cells in the brain and fight the effect of cellular oxidation, making Acetyl-L-Carnitine a potent anti-aging agent.

Lipofuscin, damaged fat cells known as „age spots“ when they appear on the skin, also occur in the brain. They are highly associated with poor memory, age-related neurological disorders and loss of energy. Alcar helps the brain get rid of these damaged cells and it importantly decreases the risk of neurodegenerative disorders and enhances brain function. ALCAR has also been proven to prevent deterioration of brain function during periods of stress.

Enhanced Production of Important Neurotransmitters

One of the most important benefits of ALCAR involves the acetyl groups. They are believed to provide the basis for the synthesis of the neurotransmitter acetylcholine. Acetylcholine is highly responsible for memory, learning and cognitive function. Increased Acetylcholine levels are connected to enhanced cognitive abilities. It is believed that low levels of this neurotransmitter enhance the risk of neurological disorders like Alzheimer’s and Parkinson’s disease.

Acetyl-L-Carnitine has also been proven to enhance levels of serotonin and norepinephrine, key neurotransmitters which have an important role in brain and mood function.

Actions in the Body

Acetyl-L-Carnitine also works in the body, performing many of the identical functions as L-carnitine. Although the conversion of fat to energy isn’t one of Acetyl-L-Carnitine’s primary benefits, it enhances metabolic effectiveness and provides many of the same energy-related benefits as other L-carnitine types. Acetyl-L-Carnitine has also been proven to be especially efficient at reducing insulin resistance and decreasing hypertension.



ALCAR’s benefits are really potentiated when stacked with other nootropics. ALCAR is usually included in stacks which feature nootropics in the Racetam group, allowing them to each work to their highest potential. ALCAR works in tandem with the acetylcholine system so you should include a choline precursor, like Alpha GPC, in your stack.

Piracetam and ALCAR stack

Take it once a day

  • 8 g Piracetam
  • 300 mg Alpha GPC
  • 500 mg ALCAR

Side Effects

Your kidneys and liver already synthesize small amounts of ALCAR naturally. As such, it is viewed as exceptionally safe and well-tolerated.
When taken according to the recommended levels listed above, side effects are rare. Those that are reported are minor and usually associated with higher doses. Nausea is the most commonly reported side effect. It can usually be addressed by using ALCAR with food. The second most commonly reported side effect is headache and it may be attributable to excess choline. Many people who experience headache when using ALCAR report that decreasing the amount of choline in their regimen stops the headaches.
There are many drugs which might cause some interactions with Acetyl-L-Carnitine, so before taking it in combination with Accutane (used for treating acne), AZT (AIDS and HIV), Doxorubicin (cancer)and Valproic (Depakote) acid (the anti-seizure medication) it is very important to visit your doctor for professional advice.
Also, you should visit your doctor if you want to add a new supplement to your routine.


There are many options when purchasing ALCAR in capsule form, but if you want to get a quality supplement you should choose NOW Foods Acetyl L-Carnitine or Jarrow Formulas Acetyl L-Carnitine Arginate and Alpha Lipoic Acid. Alternatively, for cheaper option, instead of capsules, ALCAR can be bought in bulk powder form.

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ALCAR is amazing natural supplement which provides many benefits for both body and brain. It is very well tolerated, affordable, and safe and you do not need a prescription to get it. ALCAR is supplement to try for anyone who is interested in better defence against aging, better health and better cognitive abilities.

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