CDP Choline


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CDP Choline, also known as cytidine-diphosphate choline or citicoline, is a potent nootropic. It is best known for its ability to protect the brain against loss of memory and increase memory. But improved memory is only a part of the CDP Choline picture; it can also boost mental energy, increase focus and provide better clarity of thought. Recent researches suggest that CDP Choline may even be a helpful treatment for many medical issues, including head injuries, neurodegenerative diseases, stroke, attention deficit disorder, glaucoma and even cocaine dependency.


Product Description:

CDP Choline is not a laboratory created compound. It exists naturally and it is produced in the human body as the most active form of Choline. As a source of Choline, CDP Choline is able to boost acetylcholine in the brain. Acetylcholine is the crucial neurotransmitter for learning and synaptic plasticity. CDP Choline is also used in the synthesis of cell membranes and it is linked to higher levels of several other brain chemicals and neurotransmitter.

CDP Choline, along with Centrophenoxine and Alpha GPC, are regarded the most efficient choline supplements for people who use nootropics.

General thoughts:


CDP Choline is a potent nootropic that works on its own and potentiates other nootropic supplements to increase many aspects of brain health and cognition:

  • Improved Concentration and Focus: CDP Choline can enhance the ability to concentrate for longer periods of time with less distraction. This is vital for completing any mentally demanding and complex activity, learning and mastering a new skill. Researches have proven that this is true even in the case of severe conditions, such as Alzheimer’s disease, stroke and brain injury.
  • Boosted Mental energy: It is important for everyone to maintain peak mental energy, from students facing exams to older people facing the mental slow-down often connected with aging. Studies have proven that CDP has an important positive effect on mental energy, enhancing frontal lobe bioenergetics and reducing the cognitive decline connected with aging.
  • Memory Improvement: CDP Choline is probably best known for its ability to prevent loss of memory and enhance memory. It is usually connected with anti-aging and has been tested as a potential treatment for Alzheimer’s disease.
  • Amplifying and Potentiating Other Nootropic Supplements: Many people who use nootropics consider CDP Choline an essential when constructing any combination of supplements or stack. An excellent choline source, it works especially well with Racetams, making their effects more powerful and at the same time preventing headache that is usually connected with Racetams. When used in combination with Piracetam, CDP Choline has been proven to delay onset of cognitive deterioration in Alzheimer’s disease.

How It Works

Although not enough is known about CDP Choline, there are many proofs to support that it acts through several methods of action.

CDP Choline breaks down into its individual components within the liver and is then absorbed into the blood. One of these is Choline, which works as a precursor to the neurotransmitter Acetylcholine. Because the levels of this chemical are increased, it is believed that this results in many cognitive related benefits which have been connected with CDP Choline supplementation. This is what makes it a cholinergic supplement and why individuals take it in a nootropic stack with other nootropic supplements.

Another mechanism of action is by supplying phospholipids, which make up a huge part of the cell membranes of brain tissue and neurons. Actually, the resulting substance, called phosphatidylcholine, makes up about 30 % of all the grey matter tissue within the brain.

CDP Choline is involved in the formation and development of new tissues that are used in cell membranes. This helps nerve cells and other brain cells to communicate better with one another, allowing all of your cognitive processes to run much more effectively.

Also, CDP Choline is thought to have antioxidant characteristics, aiding the body and the brain to eliminate itself of poisons and other types of toxins.


CDP Choline Dosage

CDP Choline is both safe and well tolerated so a wide range of dosages has been documented without the appearance of important side effects. The daily recommended range is between 250 and 1000 mg, either in a single dosage or in two dosages 8 to 12 hours apart. This dosage is generally considered efficient and safe. You should start on the lower side, only working your way up as necessary. Also, you shouldn’t take CDP Choline any later than the mid-afternoon, because it can increase mental energy which could result in difficulty getting to sleep.

A study conducted by MIT showed that the effects a dosage of 4000 mg were not importantly different from those of a 2000 mg dosage, which appears to indicate there is a little benefit in using very large dosages.

In general, CDP Choline is safe for most individuals to use. However, it is currently not recommended for women who are expecting a baby or women who are nursing because of a lack of studies.

CDP Choline is water soluble and it is available in both powder and capsule form.


For people who use nootropics, one of the most important aspects of CDP Choline is that it acts as a potentiator for other nootropic supplements in a stack or combination. This is especially true of Racetams, because they really stand out when combined with CDP Choline. The actual dose and ratio vary depending on which of the Racetam supplements you use. If getting the most out of your nootropic stack is important to you then CDP Choline is a supplement you must try.

CDP Choline and Aniracetam Stack

Aniracetam increases cognitive abilities while creating a sedative-like and soothing effect. This stack has a notable soothing effect.

CDP Choline and Oxiracetam Stack

This popular and potent Racetam combines the cognitive enhancements of Piracetam with a huge increase in wakefulness, alertness and energy. This stack has a noticeable stimulant effect and if taken late in the day, it could potentially interfere with sleep.

CDP Choline and Pramiracetam Stack

Pramiracetam is very powerful supplement so, to achieve optimal effect, lower doses are needed. When taken with CDP Choline, Pramiracetam’s cognitive improvements, which include improvement of focus, memory, sensory perception and thought clarity, will be potentiated. This stack creates neither soothing nor stimulant effects.

CDP Choline and Piracetam Stack

This stack is excellent for overall cognitive improvement, with neither soothing nor stimulant effects.


CDP Choline is a supplement that is available in both capsule and powder form, and even as a liquid injection. It is sold under many different brand names, such as Cognizin, Ceraxon, Somazina, Jarrow. It is very important to note that bulk CDP Choline powder is up to five times cheaper than the brand name capsule option.

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Side Effects:

CDP Choline is generally regarded as very safe and well tolerated, particularly for short term use of 3 months or less. Studies and clinical trials show that CDP Choline has no reported severe side effects, even at high dosages. Toxicological tests have proven that it has no severe effects on the cholinergic system and is excellently tolerated, characteristics that make this supplement appropriate for the treatment of different disorders, traumas and diseases.

Most healthy, normal, adult individuals will not encounter any CDP Choline side effects at all. The one warning given out is that women who are expecting baby or women who are nursing should not take this supplement, simply because there is not enough information at this point to determine its safety.

Headache, nausea, chest pain, blurred vision, high or low blood pressure, insomnia, diarrhea and indigestion have been infrequently reported as possible side effects.

Most of these side effects are only seen in people who have been taking excessively high dosages of CDP Choline. Generally, the remedy would be to either discontinue use for a period of time or to decrease your dosage.



CDP Choline is a readily available, inexpensive supplement which has a powerful and growing following among people who use nootropics. CDP Choline is a choline source you need to try if you want to get the most from your nootropic stacks.

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