Pramiracetam Review

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Pramiracetam is one of the most interesting and most powerful nootropics of the Racetam group. Many people who use nootropic supplements rate Pramiracetam as their favourite, primarily because its powerful and lasting effects on focus, memory and learning. Pramiracetam works well on its own and can be great addition to other nootropic stacks, increasing and extending their effects. Pramiracetam is quickly becoming a favourite among writers, students or anyone who wants to maximize their mental abilities. It is new to many people but it is beginning to get deserved recognition as an extraordinary nootropic.

It is also important to note that it is a bit more expensive nootropic than most of the others.

Product Description:

Pramiracetam could be an excellent supplement to integrate in and out a cyclical basis as part of an overall nootropic stack routine.

Pramiracetam is discovered and developed in the 1970s by Parke-Davis. It is a synthetic derivative of Piracetam. It is an especially powerful supplement, estimated to be from 5-30 times more powerful than Piracetam. It is prescribed in Europe for treatment of ADHD, dementia, dyslexia and memory issues caused by Alzheimer’s disease and other neurological disorders and it is sold under brand names Remen, Pramistar and Neupramir.

In the US, Pramiracetam was patented in 1979 but at present USFDA didn’t approve it for any particular use. However, it has been comprehensively researched as a possible treatment for cognitive issues and loss of memory connected with brain injury and Alzheimer’s disease. Also, Pramiracetam is currently being researched as a treatment for many central nervous system disorders.

General thoughts:


Pramiracetam optimizes brain functions and provides noticeable cognitive improvement, especially with regard to memory formation and recall. Pramiracetam is often compared to Ritalin because it creates a very powerful feeling of focus along with a certain amount of emotional blunting.

More than anything, you will notice following benefits:

  • Memory Repair: In limited clinical studies, Pramiracetam has been proven to be an efficient treatment for loss of memory and other cognitive issues caused by brain injuries. Pramiracetam is also one of few nootropic supplements which have been studied in the US as potential treatment of loss of memory associated with Alzheimer’s disease and other neurological disorders. One research has even proved it to be effective of reversing chemically caused amnesia in healthy individuals.
  • Clearer Auditory and Visual Perception: People who use Pramiracetam often report improved or increased sensory perceptions, including more vivid and clearer visual perception with greater color contrast and richer and amplified sound.
  • Social Fluency: Many people who use Pramiracetam claim that using this supplement helps them completely participate and enjoy in social situation. This benefit is likely associated with the supplement’s overall brain function optimization but could also be associated with its emotional blunting effects, which may decrease social anxiety.
  • Mental Clarity and Alertness: Many people who use Pramiracetam report that using this supplement increases focus, provides clear thinking, increases focus and gives them strong feelings of mental alertness.
  • Improved Learning Capacity: People who use Pramiracetam say that using this supplement makes learning easier, quicker and more pleasurable. This can be explained by Pramiracetam’s facilitation of greater neuroplasticity.
  • Improved Long and Short Term Memory: Pramiracetam stimulates the hippocampus, the area of the brain responsible for the formation of new memories and this is why Pramiracetam is known as a very potent memory booster. Most people who use Pramiracetam report notable improvement in memory formation and speed of recall.


How It Works

Like most Racetams, Pramiracetam stimulates the release of neurotransmitter Acetylcholine, brain chemical that transmits signals between the neurons. There are about 86 billion neurons in human brain and most of communication between these neurons happens by way of neurotransmitters. Every neuron is linked with 1,000 to 100,000 other neurons at synapses. You can optimize your neural pathways or make dramatic changes to your cognitive functions with even a small increase in levels of Acetylcholine or stimulation of these synaptic receptors.

Pramiracetam works by binding to these Acetylcholine receptors and modulating them to enhance effectiveness and efficiency of Acetylcholine transmission. It is known that this neurotransmitter is crucial in the memory formation.

New memories are formed when a synapse is created between two neurons representing related concepts. You can enhance the memory capacity of your brain with enhanced stimulation of the cholinergic system and higher amounts of Acetylcholine available in your brain.

As the computational power and synaptic plasticity of the brain enhances, you will notice enhancement in problem solving and other forms of information processing and calculations.

Pramiracetam is fat soluble, which means that is absorbed into the bloodstream via fatty acids. It reaches maximum bioavailability and peak concentrations relatively fast, usually within half an hour, and it has a relatively long half-life of 4-6 hours.

Unlike many other Racetams, Pramiracetam doesn’t seem to strongly change either emotional states or wakefulness. This can be explained by Pramiracetam’s very limited effect on the production and release of dopamine, serotonin and GABA. These are neurotransmitters which have the strongest effect on anxiety and mood levels.


Although Pramiracetam is usually very well-tolerated even at high doses, individual reactions vary. This is why it is very important for each individual to find their own optimal dose to maximize benefits.

Recommendations on the most efficient daily dosage vary considerably because of the lack of adequate scientific researches. It is recommended to start with 150 mg a day at first and build up to a dose of 300-1200 mg depending on your needs. This can be taken all at once or divided into two or three dosages per day. Although there are very few harmful side effects associated with Pramiracetam, it is recommended to begin with the lowest effective dosage and increase slowly as necessary.

Unless doctor says so, never exceed these recommendations. Some users have experimented with Pramiracetam mega dosages in excess of 1 gram without severe side effects. However, this practice isn’t recommended because you may have negative and unwanted reaction.

One important aspect of Pramiracetam is that in powder form it has extremely pungent taste, which most users find very distasteful. Many people who use this supplement prefer to either make their own capsules or buy Pramiracetam in capsule form.

Also, the fact that Pramiracetam is fat and not water soluble means that mixing the powder with water is impossible because it will simply float on the surface. Some people suggest mixing Pramiracetam powder with a small amount of oil. Taking this supplement with food and oil can also increase bioavailability and absorption.


Pramiracetam works well on its own, but one of the most amazing aspects is that it seems to be a strong potentiator for other nootropic supplements. It enhances their effectiveness or/and prolongs the duration of their effects. It is an especially strong potentiator for other Racetams, and that is why it is an ideal addition to most nootropic stacks.

You will find it frequently stacked with high quality choline supplements, such as Alpha GPC and Citicoline. It is known that Pramiracetam works by enhancing activity of Acetylcholine in the brain, resulting in improved working memory and focus.

Pramiracetam has very strong potency and that’s why it is usually recommended to take it on its own for a trial before stacking it with other nootropics.

Stacking Pramiracetam with a potent anti-anxiety agent, such as Aniracetam, can give you improved concentration and focus while decreasing feelings of anxiety and mental strain and promoting mood. Some people who use this supplement claim that this stack improves their public performance ability and social fluency.

Stacking Pramiracetam with an energy booster, such as Oxiracetam and Adrafinil, can increase the feeling of mental alertness and prolong it over a longer period of time.

Including choline to a Pramiracetam stack could have many positive effects. It can increase the effects of the supplement and prevent headache, which is the most commonly documented side effect of Pramiracetam.



In Europe, Pramiracetam is sold under brand names Remen, Pramistar and Neupramir.

In the US Pramiracetam is unregulated and it is not widely available. The Pramiracetam powder is much cheaper than tablet or pill format so most people decide to purchase it in powder form. If you want to buy it in powder form,  one of the best brands is NootroStop and if you want to buy it in capsule form, some of the best brands are Absorb Health and SCFC.

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Pramiracetam Side Effects:

Although Pramiracetam is much more powerful than some of the milder nootropic supplements it is generally considered to be well-tolerated and safe. There have been only few Pramiracetam side effects documented and no severe overdoses on record.

The most commonly reported side effects are fatigue and headache, and these can generally be eliminated fairly easily by the addition of choline supplement. Less common side effects, such as feelings of agitation or nervousness, insomnia and gastrointestinal distress, are usually connected with high dosage and can usually be eliminated by decreasing dosage.

Pramiracetam does not cause addiction and no important harmful effects of long-term use have been reported. There are also some proofs that Pramiracetam can restore function in aging brains and improve brain health.


Pramiracetam is very strong nootropic. Despite the fact that is relatively new on the market, it is rapidly growing in popularity. Pramiracetam is powerful, quick acting, safe and relatively long lasting. It has been proven to be an excellent nootropic supplement for writers, researchers, students, or anyone who wants greater speed of thought, focus and clarity, faster recall and better memory.


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